Antidepressant-induced hepatotoxicity research paper

The efficacy of Ginkgo biloba on cognitive function in Alzheimer disease. To determine the effect of treatment with Ginkgo biloba extract on objective measures of cognitive function in patients with Alzheimer disease AD based on formal review of the current literature.

Antidepressant-induced hepatotoxicity research paper

This genotype association was found in Discussion In this observational cohort study, we showed that evaluation of an LFT is infrequently performed in depressed patients without current alcohol dependence, drug abuse or unstable medical conditions, which require starting an antidepressant treatment, by a psychiatrist.

This suggests that psychiatrists are not aware of antidepressant induced DILI.

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We were not able to identify clear criteria for assessment of LFTs except that they were more often conducted with inpatients, and had higher triglyceride serum levels. Nevertheless, the prevalence of LFT abnormalities was high reaching at least 7. Recommendations are therefore needed for assessment of LFT in depressed patients treated with antidepressants beyond those with current alcohol dependence, drug abuse or unstable medical conditions.

There are no recommendations regarding liver function testing in patients taking antidepressant medication.

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Furthermore, clinical trials evaluating LFTs exist only for newer drugs. Therefore, DILI related to antidepressant use is probably underdiagnosed in clinical practice [ 8 ].

Antidepressant-induced hepatotoxicity research paper

In our cohort, only Most patients showed an altered LFT at baseline arguing against a drug-induced hepatic toxicity. Metabolic syndrome and metabolic syndrome components waist circumference, hypertension and serum triglycerides were more frequent in antidepressant-treated patients with LFT abnormalities.

Acute alcohol consumption and chronic hepatitis C virus infection were also involved. Nevertheless, alcohol relapse was the second most common cause of LFT abnormalities and should be considered in antidepressant-treated patients.

These data suggest that an increase in aminotransferase levels before any antidepressant treatment or during treatment may be related to an underlying liver disease, not necessarily severe, that does not contraindicate antidepressant treatment.

Therefore, assessment of baseline LFTs may be useful as they help to interpret the abnormal LFT results during antidepressant treatment. Abnormal results may be a manifestation of either underlying liver disease or antidepressant-induced hepatotoxicity. These patients did not meet the criteria for metabolic syndrome.

Moreover, etiological data such as viral hepatitis status, autoimmune hepatitis markers, ultrasound exploration or liver biopsy were not available. An increase of carbohydrate or fat intake may also lead to an increase of baseline aminotransferase levels in only three days [ 25 ].

For this reason, we cannot exclude that these LFT abnormalities were related to physiological variations, the concomitant medication or the previous exposure to antidepressants.

Surveillance of the LFT once abnormalities are detected may therefore be useful in patients receiving antidepressant medication to discriminate between physiological variations and possible drug-related toxicity.

A more recent study conducted in medical inpatients reported a DILI incidence of 1.Case reports and letters relating to hepatotoxicity from antidepressant overdose were Synthesis:Antidepressant-induced liver injury described in published cases were of the idiopathic type and, by definition, cannot be predicted based on dose or specific risk factors.

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The Australian National Health and Medical Research Council is considering a similar recommendation. That paper has not been updated in light of the more extensive independent studies.

adherence. Rinaldi A. Fava M Suppl editors. Heber KR. Bacon CG.

Antidepressant-induced hepatotoxicity research paper

Estimating the prevalence and impact of antidepressant-induced sexual. Primary care physicians, therefore, constitute a critical link in detecting and appropriately referring patients with bipolar disorder, and are vital for helping to manage a major component of the burden of illness in the community.

RESULTS: Although data on antidepressant-induced liver injury are scarce, %-3% of patients treated with antidepressants may develop asymptomatic mild elevation of serum aminotransferase levels.

All antidepressants can induce hepatotoxicity, especially in elderly patients and those with polypharmacy. Thesis statement about loyalty shapes of such traits i do not see more as they have to be studied well.

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