Functional magnetic resonance imaging and spectroscopic

Play media Visualization of the T1 and T2 relaxation times. The process of population relaxation refers to nuclear spins that return to thermodynamic equilibrium in the magnet. This process is also called T1" spin-lattice " or "longitudinal magnetic" relaxation, where T1 refers to the mean time for an individual nucleus to return to its thermal equilibrium state of the spins. After the nuclear spin population has relaxed, it can be probed again, since it is in the initial, equilibrium mixed state.

Functional magnetic resonance imaging and spectroscopic

When nerve cells are active they consume oxygen carried by hemoglobin in red blood cells from local capillaries. The local response to this oxygen utilization is an increase in blood flow to regions of increased neural activity, occurring after a delay of approximately seconds.

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This hemodynamic response rises to a peak over seconds, before falling back to baseline and typically undershooting slightly. This leads to local changes in the relative concentration of oxyhemoglobin and deoxyhemoglobin and changes in local cerebral blood volume in addition to this change in local cerebral blood flow.

Functional magnetic resonance imaging and spectroscopic

Hemoglobin is diamagnetic when oxygenated but paramagnetic when deoxygenated. The magnetic resonance MR signal of blood is therefore slightly different depending on the level of oxygenation.

These differential signals can be detected using an appropriate MR pulse sequence as blood-oxygen-level dependent BOLD contrast. Higher BOLD signal intensities arise from decreases in the concentration of deoxygenated hemoglobin since the blood magnetic susceptibility now more closely matches the tissue magnetic susceptibility.

By collecting data in an MRI scanner with parameters sensitive to changes in magnetic susceptibility one can assess changes in BOLD contrast. These changes can be either positive or negative depending upon the relative changes in both cerebral blood flow CBF and oxygen consumption.

In general, changes in BOLD signal are well correlated with changes in blood flow. Numerous studies during the past several decades have identified a coupling between blood flow and metabolic rate ; that is, the blood supply is tightly regulated in space and time to provide the nutrients for brain metabolism.

While current data indicate that local field potentialsan index of integrated electrical activity, form a marginally better correlation with blood flow than the spiking action potentials that are most directly associated with neural communication, no simple measure of electrical activity to date has provided an adequate correlation with metabolism and the blood supply across a wide dynamic range.

Presumably, this reflects the complex nature of metabolic processes, which form a superset with regards to electrical activity.

Some recent results have suggested that the increase in cerebral blood flow CBF following neural activity is not causally related to the metabolic demands of the brain region, but rather is driven by the presence of neurotransmittersespecially glutamate.

Some other recent results suggest that an initial small, negative dip before the main positive BOLD signal is more highly localized and also correlates with measured local decreases in tissue oxygen concentration perhaps reflecting increased local metabolism during neuron activation.

Use of this more localized negative BOLD signal has enabled imaging of human ocular dominance columns in primary visual cortex, with resolution of about 0. One problem with this technique is that the early negative BOLD signal is small and can only be seen using larger scanners with magnetic fields of at least 3 teslas.

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Further, the signal is much smaller than the normal BOLD signal, making extraction of the signal from noise that much more difficult. Also, this initial dip occurs within seconds of stimulus initiation, which may not be captured when signals are recorded at long repetition TR.

If the TR is sufficiently low, increased speed of the cerebral blood flow response due to consumption of vasoactive drugs such as caffeine [1] or natural differences in vascular responsivnesses may further obscure observation of the initial dip.

Experimental results indicate that the BOLD signal can be weighted to the smaller vessels, and hence closer to the active neurons, by using larger magnetic fields.

Furthermore, the size of the BOLD signal increases roughly as the square of the magnetic field strength.

Hence there has been a push for larger field scanners to both improve localization and increase the signal. A few 7 tesla commercial scanners have become operational, and experimental 8 and 9 tesla scanners are under development. Such images can be acquired with moderately good spatial and temporal resolution; images are usually taken every 1—4 seconds, and the voxels in the resulting image typically represent cubes of tissue about 2—4 millimeters on each side in humans.

Recent technical advancements, such as the use of high magnetic fields and advanced "multichannel" RF reception, have advanced spatial resolution to the millimeter scale. Although responses to stimuli presented as close together as one or two seconds can be distinguished from one another, using a method known as event-related fMRI, the full time course of a BOLD response to a briefly presented stimulus lasts about 15 seconds for the robust positive response.

Researchers should have a reasonable understanding of the physical principles underlying fMRI. This allows for more detailed theory testing and inference on perceptual and cognitive processes, and allows to relate these to specific brain structures.

The fMRI signals can be put into the context of previous knowledge only with an understanding of the neuroanatomy. Ultimately, the goal of all functional imaging experiments is to explain human cognition and behavior in terms of physical anatomical mechanisms.

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Correct application of statistics is essential to "tease out" observations and avoid false-positive results. Familiarity with neuronal behavior at the electrophysiological level can help investigators design a useful fMRI study.

Since its inception, fMRI has been strongly criticised, both as a research technique and in the way its results have been interpreted. Criticisms leveled at fMRI The BOLD signal is only an indirect measure of neural activity, and is therefore susceptible to influence by non-neural changes in the body.

BOLD signals are most strongly associated with the input to a given area than with the output.Sriram Venneti and colleagues examine non-invasive metabolic imaging strategies that can be used to interrogate some of the genomic alterations in brain tumours, with .

Magnetic resonance imaging (MRI) is a technique used in biomedical imaging and radiology to visualize internal structures of the body. Because MRI provides excellent contrast between different soft tissues, the technique is especially useful for diagnostic imaging of the brain, muscles, and heart..

In the past 20 years, MRI technology has improved significantly with the introduction of systems. Arxivsorter ranks papers from based on your own interests.. It simply asks for a few favorite authors and then estimates the relevance of arbitrary papers using information from authorship proximity and semantic similarity..

It is not a filter and therefore does not lose any information. Plenary Speakers. Juergen Czarske TU Dresden, Germany. TBA. Speech title: TBA. Abstract: TBA Chunlei Guo Duke University, USA.

TBA Speech title: TBA. Abstract: TBA. This tutorial/review covers functional brain-imaging methods and results used to study language and reading disabilities.

Although the main focus is on functional MRI and functional MR spectroscopy, other imaging techniques are discussed briefly such as positron emission tomography (PET), electroencephalography (EEG), .

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Magnetic resonance imaging - Wikipedia